A calcium-driven mechanochemical model for prediction of force generation in smooth muscle.

  title={A calcium-driven mechanochemical model for prediction of force generation in smooth muscle.},
  author={Sae-Il Murtada and Martin Kroon and Gerhard A Holzapfel},
  journal={Biomechanics and modeling in mechanobiology},
  volume={9 6},
A new model for the mechanochemical response of smooth muscle is presented. The focus is on the response of the actin-myosin complex and on the related generation of force (or stress). The chemical (kinetic) model describes the cross-bridge interactions with the thin filament in which the calcium-dependent myosin phosphorylation is the only regulatory mechanism. The new mechanical model is based on Hill's three-component model and it includes one internal state variable that describes the… CONTINUE READING


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