A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.

Abstract

Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration and considered as an endoplasmic reticulum (ER) disease. Despite the underlying importance of ER dysfunction in Wolfram syndrome and the identification of two causative genes, Wolfram syndrome 1 (WFS1) and Wolfram syndrome 2 (WFS2), a molecular mechanism linking the ER to… (More)
DOI: 10.1073/pnas.1421055111

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@article{Lu2014ACP, title={A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.}, author={Simin Lu and Kohsuke Kanekura and Takashi Hara and Jana Mahadevan and Larry D. Spears and Christine M. Oslowski and Rita J. Martinez and Mayu Yamazaki-Inoue and Masashi Toyoda and Amber Neilson and Patrick M. Blanner and Cris M Brown and Clay F. Semenkovich and Bess A. Marshall and Tamara Hershey and Akihiro Umezawa and Peter A. Greer and Fumihiko Urano}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2014}, volume={111 49}, pages={E5292-301} }