A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans

@article{Schafer1995ACH,
  title={A calcium-channel homologue required for adaptation to dopamine and serotonin in Caenorhabditis elegans},
  author={William R. Schafer and Cynthia J. Kenyon},
  journal={Nature},
  year={1995},
  volume={375},
  pages={73-78}
}
PROCESSING and storage of information by the nervous system requires the ability to modulate the response of excitable cells to neurotransmitter. A simple process of this type, known as adaptation or desensitization, occurs when prolonged stimulation triggers processes that attenuate the response to neurotransmitter. Here we report that the Caenorhabditis elegans gene unc-2 is required for adaptation to two neurotransmitters, dopamine and serotonin. A loss-of-function mutation in unc-2 resulted… CONTINUE READING
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