A calcitonin gene-related peptide receptor antagonist prevents the development of tolerance to spinal morphine analgesia.

@article{Menard1996ACG,
  title={A calcitonin gene-related peptide receptor antagonist prevents the development of tolerance to spinal morphine analgesia.},
  author={Dan Menard and D van Rossum and Satyabrata Kar and S J St Pierre and Maaja Sutak and K. H. Jhamandas and R{\'e}mi Quirion},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 7},
  pages={2342-51}
}
Tolerance to morphine analgesia is believed to result from a neuronal adaptation produced by continuous drug administration, although the precise mechanisms involved have yet to be established. Recently, we reported selective alterations in rat spinal calcitonin gene-related peptide (CGRP) markers in morphine-tolerant animals. In fact, increases in CGRP-like immunostaining and decrements in specific [125]hCGRP binding in the superficial laminae of the dorsal horn were correlated with the… CONTINUE READING
32 Citations
56 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Calcitonin gene-rclatcd peptide immunoreactivity

  • SJ Gibson, JM Polak, +8 authors MG Rosenfeld
  • 1984
Highly Influential
5 Excerpts

1995a) Tolerance to the antinociceptive properties of morphine in the rat

  • D Menard, D van Rossum, S Kar, F Jolicoeur, K Jhamandas, R Quirion
  • 1995
4 Excerpts

Alteration of calcitonin gcnc-related pcptidc and its receptor binding sites during the development of tolerance to mu and delta-induced analgesia

  • D Menard, D van Rossum, S Kar, R Quirion
  • Can J Physiol Pharmacol
  • 1995
3 Excerpts

CCK receptor activation may prcvcnt tolerance to morphine in mice

  • M Rczaydt, S Nikfar, M-R Zarrindast
  • Eur J Pharmacol
  • 1994

Cholecys - tokinin and morphine analgesia : variations on a theme

  • L Stanfa, A Dickenson, Xu X-J, Z Wiesenfeld-Hallin
  • Trends Phar - macol Sci
  • 1994

Similar Papers

Loading similar papers…