A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.

@article{Lin1996ACH,
  title={A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.},
  author={Xin Lin and Daniel L Barber},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 22},
  pages={
          12631-6
        }
}
Activation of the ubiquitously expressed Na-H exchanger, NHE1, results in an increased efflux of intracellular H+. The increase in intracellular pH associated with this H+ efflux may contribute to regulating cell proliferation, differentiation, and neoplastic transformation. Although NHE1 activity is stimulated by growth factors and hormones acting through multiple GTPase-mediated pathways, little is known about how the exchanger is directly regulated. Using expression library screening, we… CONTINUE READING
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