A cadmium-transporting P1B-type ATPase in yeast Saccharomyces cerevisiae.

  title={A cadmium-transporting P1B-type ATPase in yeast Saccharomyces cerevisiae.},
  author={David J. Adle and Devis Sinani and Heejeong Kim and Jaekwon Lee},
  journal={The Journal of biological chemistry},
  volume={282 2},
Detoxification and homeostatic acquisition of metal ions are vital for all living organisms. We have identified PCA1 in yeast Saccharomyces cerevisiae as an overexpression suppressor of copper toxicity. PCA1 possesses signatures of a P1B-type heavy metal-transporting ATPase that is widely distributed from bacteria to humans. Copper resistance conferred by PCA1 is not dependent on catalytic activity, but it appears that a cysteine-rich region located in the N terminus sequesters copper… CONTINUE READING


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