A cGMP-signaling pathway in a subset of olfactory sensory neurons.

  title={A cGMP-signaling pathway in a subset of olfactory sensory neurons.},
  author={Mike R Meyer and A Bukauskiene Angele and Elisabeth Kremmer and Ulrich Benjamin Kaupp and Fredrik Muller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 19},
It is well established that signal transduction in sensory neurons of the rat olfactory epithelium involves a cAMP-signaling pathway. However, a small number of olfactory neurons specifically express cGMP-signaling components, namely a guanylyl cyclase (GC-D) and a cGMP-stimulated phosphodiesterase (PDE2). Here, we show that this subset of olfactory neurons expressing GC-D and PDE2 does also express the subunit of a cGMP-selective cyclic nucleotide-gated (CNG) channel that has been previously… CONTINUE READING
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University of Texas Southwestern Medical Center, Dallas, TX, and approved

  • David L. Garbers
  • July 10,
  • 2000

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