A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site.

@article{Connolly1993ACC,
  title={A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site.},
  author={Damian Connolly and Lisa A. Cotterill and Rosemarie Hederer and Christopher J. Thorpe and Paul Travers and John H Mcvey and Julian P. Dyson and Peter J. Robinson},
  journal={Journal of immunology},
  year={1993},
  volume={151 11},
  pages={6089-98}
}
We have isolated a cDNA clone which encodes the Qa-1a histocompatibility Ag from a library prepared from Con A-activated B10.BR mouse spleen cells. The clone encodes a protein of 322 amino acids with three potential N-glycosylation sites. The coding sequence shows strongest similarity with that of the T23d gene of DBA/2 mice which encodes the Qa-1b molecule. Molecular modeling of the putative peptide-combining site indicates most of the differences between Qa-1a and Qa-1b are located peripheral… CONTINUE READING
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