A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis.

  title={A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis.},
  author={Ngan K Vo and Matthew E. Klein and O. A. Varlamova and David M Keller and Tadashi Yamamoto and Richard H. Goodman and Soren Impey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 45},
  • N. VoMatthew E. Klein S. Impey
  • Published 8 November 2005
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
MicroRNAs (miRNAs) regulate cellular fate by controlling the stability or translation of mRNA transcripts. Although the spatial and temporal patterning of miRNA expression is tightly controlled, little is known about signals that induce their expression nor mechanisms of their transcriptional regulation. Furthermore, few miRNA targets have been validated experimentally. The miRNA, miR132, was identified through a genome-wide screen as a target of the transcription factor, cAMP-response element… 

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