A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

@article{Ham1995ACD,
  title={A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death},
  author={Jonathan Ham and Carol M Babij and Jonathan M. Whitfield and Curt M Pfarr and Dominique Lallemand and M. Yaniv and Lee L Rubin},
  journal={Neuron},
  year={1995},
  volume={14},
  pages={927-939}
}
Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family member. When sympathetic neurons are deprived of NGF, the level of c-Jun protein significantly increases, whereas the levels of the other members of the Jun and Fos family remain relatively constant. c-Jun also becomes more… CONTINUE READING
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