A c-Jun activation domain peptide and its corresponding phosphopeptide have potential to adopt alpha-helical conformation.

@article{John1996ACA,
  title={A c-Jun activation domain peptide and its corresponding phosphopeptide have potential to adopt alpha-helical conformation.},
  author={Michael John and Jean Paul Briand and Manfred Schnarr},
  journal={Peptide research},
  year={1996},
  volume={9 2},
  pages={71-8}
}
The c-Jun transcription factor contains a transactivation domain that belongs to the "acidic" type of transcription activator. To determine the secondary structure of the Jun activation domain, we synthesized a peptide corresponding to amino acids 61 to 98 of c-Jun. Jun N-terminal kinases are able to phosphorylate Ser-63 and Ser-73 in vivo, which… CONTINUE READING