A bystander cell-based GM-CSF secreting vaccine synergized with a low dose of cyclophosphamide presents therapeutic immune responses against murine hepatocellular carcinoma

@article{Chen2013ABC,
  title={A bystander cell-based GM-CSF secreting vaccine synergized with a low dose of cyclophosphamide presents therapeutic immune responses against murine hepatocellular carcinoma},
  author={Chen Chen and Jiajie Hou and Zhe Lin and Ming Yao and Runqiu Jiang and Youjing Wang and Yun Gao and Qing Shao and Lei Deng and Yun Chen and Beicheng Sun},
  journal={Cellular and Molecular Immunology},
  year={2013},
  volume={10},
  pages={349-359}
}
Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreting cellular tumor vaccines contribute to the induction of potent antitumor immune responses in murine models and patients suffering from cancers. Hepatocellular carcinoma (HCC) is one of the most frequent and malignant cancers in China. We describe, for the first time, a GM-CSF releasing vaccine strategy that represents a step toward combating this type of cancer. In this study, a bystander cell-based GM-CSF secreting vaccine… CONTINUE READING

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