A bufadienolide-loaded submicron emulsion for oral administration: stability, antitumor efficacy and toxicity.


The purpose of this study was to develop an alternative submicron emulsion containing three bufadienolides for oral administration and evaluate its preclinical stability, efficacy, and toxicity. The bufadienolide-loaded oral submicron emulsion (BU-OE) was prepared by high-pressure homogenization. The storage stability, in vitro cytotoxicity, in vivo… (More)
DOI: 10.1016/j.ijpharm.2014.12.054


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