A broadly neutralizing monoclonal antibody that recognizes the V3 region of human immunodeficiency virus type 1 glycoprotein gp120.

@article{Ohno1991ABN,
  title={A broadly neutralizing monoclonal antibody that recognizes the V3 region of human immunodeficiency virus type 1 glycoprotein gp120.},
  author={Terufumi Ohno and Masaaki Terada and Yoshihiro Yoneda and Kathleen Shea and Rita Chambers and Deborah M. Stroka and Mitsuyasu Nakamura and Donald Kufe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 23},
  pages={10726-9}
}
Previous studies have demonstrated that the principal neutralizing determinant of human immunodeficiency virus type 1 (HIV-1) is located in the V3 loop of glycoprotein gp120. Antibodies prepared against this region using gp120 or peptides as immunogens have been predominantly HIV-1-isolate-specific. In the present studies, murine monoclonal antibodies (mAbs) were prepared against the HIV-1MN strain. One mAb, designated NM-01, was selected for its ability to neutralize both the MN and IIIB… CONTINUE READING