• DOI:10.1089/AID.1994.10.1651
Corpus ID: 38814749

A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1.

@article{Purtscher1994ABN,
  title={A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1.},
  author={M. Purtscher and A. Trkola and G. Gruber and A. Buchacher and R. Predl and F. Steindl and C. Tauer and R. Berger and N. Barrett and A. Jungbauer},
  journal={AIDS research and human retroviruses},
  year={1994},
  volume={10 12},
  pages={
          1651-8
        }
}

M. Purtscher, A. Trkola, +7 authors A. Jungbauer

Published 1994

Biology, Medicine

AIDS research and human retroviruses

We have established a hybridoma clone, designated 2F5, secreting a neutralizing human monoclonal antibody (MAb) specific for gp41 of human immunodeficiency virus type 1 (HIV-1). The epitope of MAb 2F5 was mapped to amino acid sequence Glu-Leu-Asp-Lys-Trp-Ala on the ectodomain of gp41. In this study different in vitro test systems were used to characterize the neutralizing properties of MAb 2F5. In syncytium inhibition assays, fusion inhibition experiments, and neutralization assays on different… CONTINUE READING

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