A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1.

@article{Purtscher1994ABN,
  title={A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1.},
  author={Martin Purtscher and Alexandra Trkola and Gerhard Gruber and Andrea Buchacher and Renate Predl and Franz Steindl and C Tauer and Rudolf Berger and Nicholas Barrett and Alois Jungbauer},
  journal={AIDS research and human retroviruses},
  year={1994},
  volume={10 12},
  pages={
          1651-8
        }
}
We have established a hybridoma clone, designated 2F5, secreting a neutralizing human monoclonal antibody (MAb) specific for gp41 of human immunodeficiency virus type 1 (HIV-1). The epitope of MAb 2F5 was mapped to amino acid sequence Glu-Leu-Asp-Lys-Trp-Ala on the ectodomain of gp41. In this study different in vitro test systems were used to characterize the neutralizing properties of MAb 2F5. In syncytium inhibition assays, fusion inhibition experiments, and neutralization assays on different… 
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TLDR
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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1
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Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41
TLDR
The results suggest that a rather extensive region of gp41 close to the transmembrane domain is accessible to neutralizing Abs and could form a useful target for vaccine design.
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TLDR
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TLDR
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TLDR
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TLDR
Broadly neutralizing monoclonal antibodies are potentially important tools in human immunodeficiency virus type 1 (HIV-1) vaccine design and have implications for passive-immunization studies in countries where clade C viruses are common, given that only MAbs b12 and 4E10 were effective against viruses from this clade.
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Monoclonal Antibodies Recognizing HIV-1 gp41 Could Inhibit Env-Mediated Syncytium Formation
Some monoclonal antibodies (mAbs) could inhibit infection by HIV-1. In this study, four mAbs against HIV-1 gp41 were prepared in mice. All four mAbs could bind to the recombinant soluble gp41 and…
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TLDR
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