A broadly neuroprotective derivative of curcumin

@article{Liu2008ABN,
  title={A broadly neuroprotective derivative of curcumin},
  author={Yuanbin Liu and Richard Dargusch and Pamela Maher and David R. Schubert},
  journal={Journal of Neurochemistry},
  year={2008},
  volume={105}
}
The plant polyphenolic curcumin alters the response of nerve cells to some forms of toxic stress. The steroid‐like compound, cyclohexyl bisphenol A, has broad neuroprotective properties that are very distinct from those of curcumin. To incorporate both families of biological activities into a single molecule, a pyrazole derivative of curcumin, called CNB‐001, was synthesized. CNB‐001 acquires a new activity and is far superior in neuroprotection assays to either parental molecule, but retains… 
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