A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens.

@article{Valentino2011ABA,
  title={A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens.},
  author={Michael D. Valentino and C. Siddiq Abdul-Alim and Zachary J. Maben and Denise Skrombolas and Lucinda L. Hensley and Thomas H Kawula and Michelle Dziejman and Edith M. Lord and Jeffrey A Frelinger and John G. Frelinger},
  journal={Journal of immunological methods},
  year={2011},
  volume={373 1-2},
  pages={
          111-26
        }
}
Epitopes are a hallmark of the antigen specific immune response. The identification and characterization of epitopes is essential for modern immunologic studies, from investigating cellular responses against tumors to understanding host/pathogen interactions especially in the case of bacteria with intracellular residence. Here, we have utilized a novel approach to identify T cell epitopes exploiting the exquisite ability of particulate antigens, in the form of beads, to deliver exogenous… CONTINUE READING
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