A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis.

@article{Monach2009ABS,
  title={A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis.},
  author={Paul Monach and Wolfgang Hueber and Benedikt Kessler and Beren H. Tomooka and Maya J Benbarak and Barry P. Simmons and John L. Wright and Thomas S. Thornhill and Marc Monestier and Hidde L. Ploegh and William H Robinson and Diane Mathis and Christophe Benoist},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 37},
  pages={15867-72}
}
Deposits of Ig and complement are abundant in affected joints of patients with rheumatoid arthritis (RA) and in animal models of RA in which antibodies are demonstrably pathogenic. To identify molecular targets of the Igs deposited in arthritic joints, which may activate local inflammation, we used a combination of mass spectrometry (MS) and protein microarrays. Immune complexes were affinity-purified from surgically removed joint tissues of 26 RA and osteoarthritis (OA) patients. Proteins… CONTINUE READING

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