A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

@article{Gao2013ABA,
  title={A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.},
  author={Yinghong Gao and Stephen P. Davies and Martin Augustin and Anna M. Woodward and Umesh A. Patel and Robert Kovelman and Kevin James Harvey},
  journal={The Biochemical journal},
  year={2013},
  volume={451 2},
  pages={313-28}
}
Despite the development of a number of efficacious kinase inhibitors, the strategies for rational design of these compounds have been limited by target promiscuity. In an effort to better understand the nature of kinase inhibition across the kinome, especially as it relates to off-target effects, we screened a well-defined collection of kinase inhibitors using biochemical assays for inhibitory activity against 234 active human kinases and kinase complexes, representing all branches of the… CONTINUE READING