A bright future of researching AMPA receptor agonists for depression treatment

@article{Yang2012ABF,
  title={A bright future of researching AMPA receptor agonists for depression treatment},
  author={Chun Yang and Wei Zhou and Xiaoming Li and Jianjun Yang and Bernadeta Szewczyk and Agnieszka Pałucha-Poniewiera and Ewa Poleszak and Andrzej Pilc and Gabriel Nowak},
  journal={Expert Opinion on Investigational Drugs},
  year={2012},
  volume={21},
  pages={583 - 585}
}
  • Chun Yang, W. Zhou, G. Nowak
  • Published 12 April 2012
  • Psychology, Biology
  • Expert Opinion on Investigational Drugs
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is a widely used drug for anesthesia. However, increasing studies have focused on the potential antidepressant effects of ketamine. As mentioned in the review of Szewczyk et al. [1], subunit selective NMDA receptor antagonists exert the same antidepressant efficacy of ketamine but with fewer adverse effects. Indeed, the authors make a good comment and indicate a bright research future of developing novel antidepressants. However, we… 
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Ketamine has become a standard tool for identifying the biological factors associated with rapid antidepressant action and, as such, is a novel target for the development of new therapeutics.
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TLDR
Data from mutant mice suggest that AMPA receptors may regulate the expression of brain-derived neurotrophic factor, a neurotrophin which has been implicated in the actions of antidepressant therapies, and that compounds which target AMPA receptor receptors may prove useful in the clinical management of depression.
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Zinc administration potentiated a veratridine-evoked glutamate and aspartate release in the rat’s prefrontal cortex and hippocampus and indicates the involvement of the NMDA and AMPA glutamatergic receptors in this activity.
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It is found that repeated administration of MGS0039 attenuated OB-related deficits, confirming antidepressant-like activity of the tested compound, and the mechanism of action of group II mGlu receptor antagonists differs from that of typical antidepressants, such as SSRIs.
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