A brief photochemically induced oxidative insult causes irreversible lens damage and cataract. II. Mechanism of action.

@article{Spector1995ABP,
  title={A brief photochemically induced oxidative insult causes irreversible lens damage and cataract. II. Mechanism of action.},
  author={Abraham Spector and Guo-ming Wang and Ruiqi R Wang and Win C. Li and Norman Jay Kleiman},
  journal={Experimental eye research},
  year={1995},
  volume={60 5},
  pages={
          483-93
        }
}
Using photochemically induced oxidative stress and rat lenses in organ culture with 4% O2 and 4 microM riboflavin, it has been found that the observed changes in lens parameters are, in most cases, irreversible. This has made possible the elucidation of the sequence of biological changes leading to cataract. The earliest detectable changes in lens cell biology are observed in the epithelial cell redox set point and at the DNA level in terms of DNA integrity and 3H-thymidine incorporation… CONTINUE READING
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