A brief period of retrograde hyperthermic perfusion enhances myocardial protection from global ischemia: association with accumulation of Hsp 70 mRNA and protein.

@article{McCully1996ABP,
  title={A brief period of retrograde hyperthermic perfusion enhances myocardial protection from global ischemia: association with accumulation of Hsp 70 mRNA and protein.},
  author={James D McCully and Margaret M. Lotz and Irvin B. Krukenkamp and Sidney Levitsky},
  journal={Journal of molecular and cellular cardiology},
  year={1996},
  volume={28 2},
  pages={231-41}
}
The induction of heat shock proteins in the myocardium has been suggested as a possible intervention to allow for enhanced cardioprotection. We examined the cardioprotective effects of Hsp 70 induction in a clinically relevant model, in which a brief period of retrograde hyperthermic perfusion (42 degrees C) was applied for 15 min, only 5 min prior to global ischemia and reperfusion in the isolated perfused rat heart. Our results indicate that in retrograde hyperthermic perfused hearts (n = 17… CONTINUE READING

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