A brief history of oxytocin and its role in modulating psychostimulant effects

@article{Carson2013ABH,
  title={A brief history of oxytocin and its role in modulating psychostimulant effects},
  author={Dean S. Carson and Adam John Guastella and Emily R Taylor and Iain S. McGregor},
  journal={Journal of Psychopharmacology},
  year={2013},
  volume={27},
  pages={231 - 247}
}
Over the past century, the polypeptide oxytocin has played an important role in medicine with major highlights including the identification of its involvement in parturition and the milk let-down reflex. Oxytocin is now implicated in an extensive range of psychological phenomena including reward and memory processes and has been investigated as a treatment for several psychiatric disorders including addiction, anxiety, autism, and schizophrenia. In this review, we first provide an historical… 
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Beta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depression
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The Oxytocin Receptor: From Intracellular Signaling to Behavior.
TLDR
The mechanisms of OXT expression and release, expression and binding of the OXTR in brain and periphery, OX TR-coupled signaling cascades, and their involvement in behavioral outcomes are discussed to assemble a comprehensive picture of the central and peripheral OXT system.
Direct Involvement of Androgen Receptor in Oxytocin Gene Expression: Possible Relevance for Mood Disorders
TLDR
The results suggest that the fact that OXT and testosterone appear to have opposite effects in neuropsychiatric disorders might be based upon a direct inhibition of AR on OXT transcription, which may provide a novel target for therapeutic strategies in depression.
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References

SHOWING 1-10 OF 223 REFERENCES
Role of oxytocin in the neuroadaptation to drugs of abuse
TLDR
It appears that OXT inhibits the development of opiate tolerance, dependence, and self-administration as well as the acute behavioral actions of and chronic tolerance to cocaine, suggesting the possible role of this neuropeptide in the regulation of drug abuse.
Breaking the loop: Oxytocin as a potential treatment for drug addiction
TLDR
Oxytocin has fascinating potential to reverse the corrosive effects of long-term drugs abuse on social behavior and to perhaps inoculate against future vulnerability to addictive disorders.
Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating
TLDR
The results suggest that oxytocin may play an important role in the modulation of dopaminergic and glutamatergic regulation of PPI, and that it may act as a novel endogenous antipsychotic.
Oxytocin and neuroadaptation to cocaine.
  • Z. Sarnyai
  • Psychology, Medicine
    Progress in brain research
  • 1998
TLDR
A better understanding of the role of OT in neuroadaptation to cocaine may provide an insight into both the mechanisms of neuropeptide actions in the brain as well as into the neurobiology of drug addiction.
Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders
TLDR
Evidence for the existence of dopamine/oxytocin positive interaction in social behavioral paradigms and associated disorders such as sexual dysfunction, autism, addiction, anorexia/bulimia, and depression is discussed.
Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
TLDR
It is demonstrated that the anxiolytic-like profile of WAY-267464 is mediated through central sites of action, similar to the antipsychotic-like effects previously reported for OT.
Opposite effects of oxytocin and vasopressin on the emotional expression of the fear response.
TLDR
A hypothesis is developed in which neuropeptides, through their effects on distinct populations in the central amygdala, affect specific projections and specific physiological expressions of the fear response.
From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long‐term adverse consequences of drug use?
TLDR
It is concluded that oxytocin may play an important, yet largely unexplored, role in drug addiction and greater understanding of this role may ultimately lead to novel therapeutics for addiction that can improve mood and facilitate the recovery of persons with drug use disorders.
REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
TLDR
This review addresses the issues of drug design and specificity and focuses on recent findings on oxytocin and its heterotrimeric G protein‐coupled receptor OTR to highlight the role of Oxytocin in behavior and affectivity.
Oxytocin: behavioral associations and potential as a salivary biomarker.
TLDR
Using a sensitive enzyme immunoassay (EIA) and concentrated samples, the results indicate that measurements of biologically relevant changes in salivary OT are possible and support saliva as a noninvasive source to monitor central neuroendocrine function.
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