A brief history of oxytocin and its role in modulating psychostimulant effects

@article{Carson2013ABH,
  title={A brief history of oxytocin and its role in modulating psychostimulant effects},
  author={Dean S. Carson and Adam John Guastella and Emily R Taylor and Iain S. McGregor},
  journal={Journal of Psychopharmacology},
  year={2013},
  volume={27},
  pages={231 - 247}
}
Over the past century, the polypeptide oxytocin has played an important role in medicine with major highlights including the identification of its involvement in parturition and the milk let-down reflex. Oxytocin is now implicated in an extensive range of psychological phenomena including reward and memory processes and has been investigated as a treatment for several psychiatric disorders including addiction, anxiety, autism, and schizophrenia. In this review, we first provide an historical… 
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The significant increase in the desire for drug and monetary reward as well as the significant decrease in measures of social cognition was small but warrant further study of the effect of oxytocin effect in cocaine dependent subjects.
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The neurohormone oxytocin (OT) is increasingly studied for its therapeutic potential in social disorders, like autism, which are associated with the deregulation of several neurotransmission systems,…
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TLDR
The ability to fully harness the potential therapeutic benefit of targeting the brain oxytocin system may depend on the development of molecules that selectively stimulate the oxytocIn system, but that have superior pharmacokinetic properties to Oxytocin itself.
Beta-Endorphin and Oxytocin in Patients with Alcohol Use Disorder and Comorbid Depression
TLDR
Serum levels of β-endorphin and oxytocin are lower in patients with AUD, particularly in those with depressive comorbidity, and β-Endorphin levels correlated with physical aggression according to the Buss–Durkee (BDHI) estimates.
The Oxytocin Receptor: From Intracellular Signaling to Behavior.
TLDR
The mechanisms of OXT expression and release, expression and binding of the OXTR in brain and periphery, OX TR-coupled signaling cascades, and their involvement in behavioral outcomes are discussed to assemble a comprehensive picture of the central and peripheral OXT system.
Direct Involvement of Androgen Receptor in Oxytocin Gene Expression: Possible Relevance for Mood Disorders
TLDR
The results suggest that the fact that OXT and testosterone appear to have opposite effects in neuropsychiatric disorders might be based upon a direct inhibition of AR on OXT transcription, which may provide a novel target for therapeutic strategies in depression.
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