A brief history of great discoveries in pharmacology: in celebration of the centennial anniversary of the founding of the American Society of Pharmacology and Experimental Therapeutics.

@article{Rubin2007ABH,
  title={A brief history of great discoveries in pharmacology: in celebration of the centennial anniversary of the founding of the American Society of Pharmacology and Experimental Therapeutics.},
  author={Ronald P Rubin},
  journal={Pharmacological reviews},
  year={2007},
  volume={59 4},
  pages={
          289-359
        }
}
reported the excretion of large quantities of an O-methylated product, 3-methoxy-4-hydroxy-mandelic acid, by patients with pheochromocytoma, a tumor of adrenomedullary chromaffin cells. To verify that this compound was a metabolite of norepinephrine, Axelrod launched a study to identify an enzyme that would O-methylate catecholamines. He found that when an extract of rat liver was incubated with S-adenosylmethionine, catecholamine was metabolized to metanephrine, the m-O-methylated product of… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 213 REFERENCES

How acetylcholine gives rise to current at the motor end-plate.

  • The Journal of physiology
  • 2007
VIEW 31 EXCERPTS
HIGHLY INFLUENTIAL

A paradigm shift in brain research.

  • Science
  • 2001
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Miracle cure: the story of antibiotics

  • Medical History
  • 1991
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

The search for antibiotics at Rutgers University, in The History of Antibiotics (Parascandola J ed) pp 113–124

H Lechevalier
  • American Institute of the History of Pharmacy,
  • 1980
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Getting the message across

  • 1990
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

The Discovery of Insulin

M Bliss
  • 1982
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Purification of the regulatory component of adenylate cyclase.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1980
VIEW 22 EXCERPTS
HIGHLY INFLUENTIAL

Similar Papers

Loading similar papers…