• Corpus ID: 37946332

A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists.

  title={A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists.},
  author={Vincenzo Di Marzo},
  journal={Trends in pharmacological sciences},
  volume={27 3},
  • V. Di Marzo
  • Published 2006
  • Medicine
  • Trends in pharmacological sciences
British scientists have played a leading role in the long history of cannabinoid and endocannabinoid research. Such research has progressed from the first crucial evaluation of the medicinal properties of Cannabis sativa in the Western world to pioneering studies of the chemical constituents of this plant, the development of in vitro biological assays to study cannabinoids, the identification of the mechanism of action of cannabinoids, the discovery of endocannabinoids and the assessment of… 
Early phytocannabinoid chemistry to endocannabinoids and beyond
There have since been considerable advances in understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.
A drug discovery case history of ‘delta-9-tetrahydrocannabinol, cannabidiol’
This drug discovery case history reviews the preclinical and clinical development of Sativex, the first licensed phytocannabinoid-based drug approved, or in the process of approval, as therapy for indications such as MS-associated spasticity or chronic pain.
The Cannabinoid System and Male Reproductive Functions
The effects of cannabinoids and endocannabinoids, a particular group of endogenously produced cannabinoids, on male reproductive function are reviewed.
The Medicalization of Cannabis
Cannabis has been considered as both an illicit drug and a medicine throughout its history. Introduced to the UK as a medicine in the nineteenth century, its medical utility was limited and it was
Role of the Endogenous Cannabinoid System in Nicotine Addiction: Novel Insights
Recent advances on the understanding of the role of the different components of the cannabinoid system on nicotine’s effects are presented and possible alternative ways of modulating the cannabinoids system that could have implication for nicotine dependence treatment are suggested.
New resorcinol-anandamide "hybrids" as potent cannabinoid receptor ligands endowed with antinociceptive activity in vivo.
The synthesis, docking studies, and structure-activity relationships of new resorcinol-anandamide "hybrids" differing in the side chain group are reported, with results similar to that of WIN 55-212.
4 Cannabinoids and Neuropathic Pain
Cannabinoids are drugs that are either derived from cannabis or that induce similar behavioural and physiological effects to cannabis. They fall into three classes: those that are produced by plants
Cannabinoids and Vanilloids in Schizophrenia: Neurophysiological Evidence and Directions for Basic Research
Electrophysiology and viral vector-based circuit dissection, like optogenetics, can further elucidate how exogenous cannabinoids worsen or ameliorate schizophrenia symptoms, like hallucinations, delusions, and cognitive deficits.
CannabisGDB: a comprehensive genomic database for Cannabis Sativa L
Being one of the world's oldest crops with significant economic and medicinal importance, Cannabis Sativa L. (cannabis) has attracted an enormous amount of attention and become one of the most
Cannabinoid receptor ligands prevent dopaminergic neurons death induced by neurotoxic, inflammatory and oxidative stimuli in vitro
Together, these findings show an ACEA-mediated neuronal protection by means of ROS expression reduction and pro apoptotic protein caspase 3 expression inhibition in in vitro dopaminergic neurons.


The endocannabinoid system and its therapeutic exploitation
The conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come are explored.
Rimonabant: the first therapeutically relevant cannabinoid antagonist.
The data reviewed here suggest that rimonabant may constitute a new and potentially effective medication for the treatment of drug addiction and obesity-related disorders.
The endocannabinoid signaling system: Pharmacological and therapeutic aspects
The pharmacology of the endocannabinoid system is discussed, and topical CB1 agonists and CB2 agonists may prove therapeutically useful, and there is evidence that the non-steroidal inflammatory agent indomethacin produces effects secondary to activation of theendocannabinoids system.
Molecular characterization of a peripheral receptor for cannabinoids
The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids.
Evidence for novel cannabinoid receptors.
The case for as-yet-unidentified receptors implicated in the endothelium-dependent vasodilator effect of certain cannabinoids and in the presynaptic inhibition of glutamatergic neurotransmission in the hippocampus are reviewed.
The isolation and structure of delta-1-tetrahydrocannabinol and other neutral cannabinoids from hashish.
The isolation and elucidation of the structures of AMetrahydrocannabinol (A^THC), cannabigerol, cannabichromene, and cannabicyclol are described. A facile conversion of cannabidiol into A'-THC takes
The complexities of the cardiovascular actions of cannabinoids
The cardiovascular actions of cannbinoids are complex and in conscious animals, the picture is one of bradycardia followed by pressor responses, but clearly the responses to cannabinoids are dependent on the experimental conditions and synthetic cannabinoids and endocannabinoids exhibit different pharmacologies.
Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has
The molecular logic of endocannabinoid signalling
  • D. Piomelli
  • Biology, Medicine
    Nature Reviews Neuroscience
  • 2003
The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana (Cannabis). They are made
Recent developments in cannabinoid ligands.
This review presents recent developments in the structure-activity relationships of several classes of cannabinoid ligands and indicates that ligands that demonstrate high affinity for the receptors and good biological efficacy are tied together through lipophilic regions repeatedly demonstrated necessary for activity.