Corpus ID: 37946332

A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists.

@article{DiMarzo2006ABH,
  title={A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists.},
  author={Vincenzo Di Marzo},
  journal={Trends in pharmacological sciences},
  year={2006},
  volume={27 3},
  pages={
          134-40
        }
}
  • V. Di Marzo
  • Published 2006
  • Medicine
  • Trends in pharmacological sciences
British scientists have played a leading role in the long history of cannabinoid and endocannabinoid research. Such research has progressed from the first crucial evaluation of the medicinal properties of Cannabis sativa in the Western world to pioneering studies of the chemical constituents of this plant, the development of in vitro biological assays to study cannabinoids, the identification of the mechanism of action of cannabinoids, the discovery of endocannabinoids and the assessment of… Expand
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References

SHOWING 1-10 OF 71 REFERENCES
The endocannabinoid system and its therapeutic exploitation
TLDR
The conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come are explored. Expand
Rimonabant: the first therapeutically relevant cannabinoid antagonist.
TLDR
The data reviewed here suggest that rimonabant may constitute a new and potentially effective medication for the treatment of drug addiction and obesity-related disorders. Expand
Molecular characterization of a peripheral receptor for cannabinoids
TLDR
The cloning of a receptor for cannabinoids is reported that is not expressed in the brain but rather in macrophages in the marginal zone of spleen, which helps clarify the non-psychoactive effects of cannabinoids. Expand
The endocannabinoid signaling system: Pharmacological and therapeutic aspects
TLDR
The pharmacology of the endocannabinoid system is discussed, and topical CB1 agonists and CB2 agonists may prove therapeutically useful, and there is evidence that the non-steroidal inflammatory agent indomethacin produces effects secondary to activation of theendocannabinoids system. Expand
Evidence for novel cannabinoid receptors.
TLDR
The case for as-yet-unidentified receptors implicated in the endothelium-dependent vasodilator effect of certain cannabinoids and in the presynaptic inhibition of glutamatergic neurotransmission in the hippocampus are reviewed. Expand
The complexities of the cardiovascular actions of cannabinoids
TLDR
The cardiovascular actions of cannbinoids are complex and in conscious animals, the picture is one of bradycardia followed by pressor responses, but clearly the responses to cannabinoids are dependent on the experimental conditions and synthetic cannabinoids and endocannabinoids exhibit different pharmacologies. Expand
Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which hasExpand
The molecular logic of endocannabinoid signalling
  • D. Piomelli
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • 2003
The endocannabinoids are a family of lipid messengers that engage the cell surface receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana (Cannabis). They are madeExpand
Recent developments in cannabinoid ligands.
TLDR
This review presents recent developments in the structure-activity relationships of several classes of cannabinoid ligands and indicates that ligands that demonstrate high affinity for the receptors and good biological efficacy are tied together through lipophilic regions repeatedly demonstrated necessary for activity. Expand
Cannabinoids: a real prospect for pain relief?
Research on the therapeutic potential of cannabinoids has grown dramatically over the past few years. Recent advances include evidence that cannabinoid agonists are antihyperalgesic and antiallodynicExpand
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