A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

@article{Steinman2007ABH,
  title={A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage},
  author={Lawrence Steinman},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={139-145}
}
For over 35 years, immunologists have divided T-helper (TH) cells into functional subsets. T-helper type 1 (TH1) cells—long thought to mediate tissue damage—might be involved in the initiation of damage, but they do not sustain or play a decisive role in many commonly studied models of autoimmunity, allergy and microbial immunity. A major role for the… CONTINUE READING