A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes.

@article{Candido2003ABO,
  title={A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes.},
  author={Riccardo Candido and Josephine M Forbes and Merlin C Thomas and Vicki Thallas and Rachael G. Dean and Wendy C. Burns and Christos Tikellis and Rebecca H. Ritchie and Stephen Morris Twigg and Mark Emmanuel Cooper and Louise M Burrell},
  journal={Circulation research},
  year={2003},
  volume={92 7},
  pages={785-92}
}
The formation of advanced glycation end products (AGEs) on extracellular matrix components leads to accelerated increases in collagen cross linking that contributes to myocardial stiffness in diabetes. This study determined the effect of the crosslink breaker, ALT-711 on diabetes-induced cardiac disease. Streptozotocin diabetes was induced in Sprague-Dawley rats for 32 weeks. Treatment with ALT-711 (10 mg/kg) was initiated at week 16. Diabetic hearts were characterized by increased left… CONTINUE READING

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