A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

@article{Newgard2009ABA,
  title={A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.},
  author={Christopher B. Newgard and Jie An and James R. Bain and Michael J. Muehlbauer and Robert A. Moffitt Johns Hopkins University David Stevens and Lillian F. Lien and Andrea M Haqq and Svati H. Shah and Michelle E. Arlotto and Cris A. Slentz and James Rochon and Dianne Gallup and Olga Ilkayeva and Brett R. Wenner and William S. Yancy and Howard Eisenson and Gerald Musante and Richard S. Surwit and David S. Millington and Mark D Butler and Laura P. Svetkey},
  journal={Cell metabolism},
  year={2009},
  volume={9 4},
  pages={311-26}
}
Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance. To test its impact on metabolic homeostasis, we fed rats on high-fat (HF), HF with supplemented BCAA (HF/BCAA), or standard chow (SC) diets. Despite having reduced food intake and a low rate of weight gain equivalent to the SC group, HF/BCAA rats were as insulin resistant as HF rats… CONTINUE READING
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