A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

@article{Newgard2009ABA,
  title={A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.},
  author={C. Newgard and J. An and J. Bain and M. Muehlbauer and R. Stevens and L. Lien and A. Haqq and S. Shah and Michelle E. Arlotto and C. Slentz and J. Rochon and D. Gallup and O. Ilkayeva and B. Wenner and W. Yancy and Howard J. Eisenson and Gerald Musante and R. Surwit and D. Millington and M. Butler and L. Svetkey},
  journal={Cell metabolism},
  year={2009},
  volume={9 4},
  pages={
          311-26
        }
}
  • C. Newgard, J. An, +18 authors L. Svetkey
  • Published 2009
  • Medicine, Biology
  • Cell metabolism
  • Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid (BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and correlated with insulin resistance. To test its impact on metabolic homeostasis, we fed rats on high-fat (HF), HF with supplemented BCAA (HF/BCAA), or standard chow (SC) diets. Despite having reduced food intake and a low rate of weight gain equivalent to the SC group, HF/BCAA rats were as insulin resistant as HF rats… CONTINUE READING

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