A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance

@inproceedings{Jang2016ABC,
  title={A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance},
  author={Cholsoon Jang and Sungwhan F. Oh and Shogo Wada and Glenn C Rowe and Laura Xiaolei Liu and Mun Chun Chan and James Y Rhee and Atsushi Hoshino and Boa Kim and Ayon Ibrahim and Luisa G Baca and Esl Kim and Chandra C. Ghosh and Samir M Parikh and Aihua Jiang and Qingwei Chu and Daniel E. Forman and Stewart H. Lecker and Saikumari Y Krishnaiah and Joshua D. Rabinowitz and Aalim M Weljie and Joseph A. Baur and Dennis L Kasper and Zoltan Arany},
  booktitle={Nature Medicine},
  year={2016}
}
Epidemiological and experimental data implicate branched-chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms that underlie this link remain unclear. Insulin resistance in skeletal muscle stems from the excess accumulation of lipid species, a process that requires blood-borne lipids to initially traverse the blood vessel wall. How this trans-endothelial transport occurs and how it is regulated are not well understood. Here we leveraged PPARGC1a (also known as… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α

  • Y Hatazawa
  • PLoS One
  • 2015

beta-Aminoisobutyric acid induces browning of white fat and hepatic betaoxidation and is inversely correlated with cardiometabolic risk factors

  • LD Roberts
  • Cell Metab
  • 2014

Similar Papers

Loading similar papers…