A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?

@article{Barrington2017ABI,
  title={A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?},
  author={Jack Barrington and Eloise Lemarchand and Stuart M Allan},
  journal={Brain pathology},
  year={2017},
  volume={27 2},
  pages={
          205-212
        }
}
Stroke is one of the leading causes of death and disability worldwide. Inflammation plays a key role across the time course of stroke, from onset to the post-injury reparative phase days to months later. Several regulatory molecules are implicated in inflammation, but the most established inflammatory mediator of acute brain injury is the cytokine interleukin-1. Interleukin-1 is regulated by large, macromolecular complexes called inflammasomes, which play a central role in cytokine release and… CONTINUE READING
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