A brain dead donor model of porcine orthotopic cardiac transplantation for assessment of cardiac allograft preservation.

@article{Ryan2000ABD,
  title={A brain dead donor model of porcine orthotopic cardiac transplantation for assessment of cardiac allograft preservation.},
  author={Jonathon Bruce Ryan and M. K. Wilson and Mark Hicks and Anthony I Nicholson and Scott H. Kesteven and Frank Junius and Michael P. Feneley and Peter S Macdonald},
  journal={Heart, lung & circulation},
  year={2000},
  volume={9 2},
  pages={78-81}
}
BACKGROUND We aimed to develop a large animal model of orthotopic cardiac transplantation, incorporating donor brain death, to assess new methods of preservation of the donor heart. METHODS Brain death was achieved in the donor pig by inflation of a 20 cc subdural balloon 1 h prior to harvest. The donor heart was stored for 6 h with conventional hypothermic ischaemic preservation. It was then transplanted orthotopically into the recipient pig using the Lower and Shumway technique. One hour… CONTINUE READING