A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology

@inproceedings{CarbonellBallestero2014ABC,
  title={A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology},
  author={Max Carbonell-Ballestero and Salva Duran-Nebreda and Ra{\'u}l Monta{\~n}ez and Ricard V. Sol{\'e} and Javier Mac{\'i}a and Carlos Rodr{\'i}guez-Caso},
  booktitle={Nucleic acids research},
  year={2014}
}
Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly adopted strategy is to fit data to Hill-shaped curves without considering the underlying molecular mechanisms. Here we provide a novel mathematical formalization that allows prediction of the global behavior of a synthetic device by considering the actual information from the… CONTINUE READING
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References

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Synthetic Biology: A Primer. 1st edn

G. Baldwin, T. Bayer, +4 authors G. B. Stan
2012

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