A boosting approach for motif modeling using ChIP-chip data

@article{Hong2005ABA,
  title={A boosting approach for motif modeling using ChIP-chip data},
  author={Pengyu Hong and Xiaole Shirley Liu and Qing Zhou and Xin Lu and Jun S. Liu and Wing Hung Wong},
  journal={Bioinformatics},
  year={2005},
  volume={21 11},
  pages={2636-43}
}
MOTIVATION Building an accurate binding model for a transcription factor (TF) is essential to differentiate its true binding targets from those spurious ones. This is an important step toward understanding gene regulation. RESULTS This paper describes a boosting approach to modeling TF-DNA binding. Different from the widely used weight matrix model, which predicts TF-DNA binding based on a linear combination of position-specific contributions, our approach builds a TF binding classifier by… CONTINUE READING