A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase.

@article{Wallerath2005ABO,
  title={A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase.},
  author={Thomas Wallerath and Huige Li and Ute G{\"o}dtel-Ambrust and Petra M. Schwarz and Ulrich Foerstermann},
  journal={Nitric oxide : biology and chemistry},
  year={2005},
  volume={12 2},
  pages={97-104}
}
A high intake of polyphenolic compounds is likely to have beneficial effects on the cardiovascular system. Especially red wine is a rich source of polyphenols, and we have previously shown that French red wine upregulates eNOS, a protective enzyme in the cardiovascular system. The current study tested (poly)phenolic constituents of red wine for their ability to enhance eNOS expression (and the activity of a 3.5-kb human eNOS promoter) in human EA.hy 926 endothelial cells. Of the compounds… CONTINUE READING
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