A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculata

  title={A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculata},
  author={Rammohan Subramanian and Mohd Zaini Asmawi and Amirin Sadikun},
  journal={Phytochemistry Reviews},
Andrographis paniculata (Burm.f) Nees is one of the most popular and important medicinal plant of the Orient, and South East Asia. It finds mention in various forms in Indian, Chinese, Malay, Thai, Unani, and Japanese systems of medicine. The plant exhibits anti-cancer, anti-inflammatory, anti-diabetic, anti-hypertensive, anti-venom, cholestatic, hepatoprotective, anti-thrombotic, anti-retroviral, anti-microbial, anti-pyretic, anti-malarial, anti-oxidant, immunomodulatory, and cardioprotective… 

Andrographis paniculata (Burm. f.) Wall. ex Nees: A Review of Ethnobotany, Phytochemistry, and Pharmacology

Recommendations addressing extraction process, tissue culture, and adventitious rooting techniques and propagation under abiotic stress conditions for improvement of phytoconstituents are discussed concisely in this paper.

Chemical Profile and Antioxidant Properties of Andrographis producta (C. B. Clarke) Gamble

Andrographis Wall. ex Nees (Family Acanthaceae) consisting 45 species globally according to International Plant Name Index (IPNI)1 and 28 species in India where most of them have distributional range

The genome of the medicinal plant Andrographis paniculata provides insight into the biosynthesis of the bioactive diterpenoid neoandrographolide

The results demonstrate the utility of the combined genomic and transcriptomic data set generated here for the investigation of the production of the bioactive diterpenoid lactone constituents of the important medicinal herb A. paniculata.

Diterpenoid Lactones with Anti-Inflammatory Effects from the Aerial Parts of Andrographis paniculata

Andrographis paniculata (AP) has been widely used in China for centuries to treat various diseases, and especially to treat inflammation. Diterpenoid lactones are the main anti-inflammatory

A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery

Its chemical and biological properties, especially its antiviral activities against SARS-CoV-2, clinical trials on URTI, and the safety of A.paniculata, support the argument that A. paniculata is a promising natural source for drug discovery regarding COVID-19 post-infectious treatment, rather than prophylaxis.

Therapeutic potential of traditionally used medicinal plant Andrographis paniculata (Burm. F.) against diabesity

It is suggested that the effects of the extract on insulin homeostasis depend on the metabolic status of animals, and Activation of cytoprotective mechanisms could be involved in its mode of action.

Medicinal Properties of Desert Date Plants ( Balanites aegyptiaca) – An Overview

Traditional uses of B. aegyptiaca (L.) Del were scientifically proven by many studies including in vivo, in vitro and even one pilot randomized controlled trial (RCT).

Andrographolides and traditionally used Andrographis paniculata as potential adaptogens

Critical analysis of available preclinical and clinical information on Andrographis paniculata extracts and pure andrographolide strongly suggest that they are pharmacologically polyvalent and that they possess adaptogenic properties.



Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

Among the single compounds extracted from A. paniculata, andrographolide is the major one in terms of bioactive properties and abundance and arabinogalactan proteins are anti-hepatotoxic.

The Conservation of Medicinal Plants: Global Importance of Medicinal Plants

A large number of plants are used in traditional medical practices, and have been for more than 3000 years, such as in Chinese Traditional Medicine, Ayurvedic Medicine, Unani Medicine, etc., most of which probably exert therapeutic effects and would be proven as such if they were properly evaluated by Western standards.

Antioxidant, antioedema and analgesic activities of Andrographis paniculata extracts and their active constituent andrographolide

AP‐H2O was more potent than AP‐EtOH in antioxidant activities and appears to possess potent antioedema and analgesic activities compared with andrographolide.

Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in jurkat cells

Phytochemical investigation of the ethanol extract of the aerial parts of this herb resulted in the isolation of 14 compounds including flavonoids and labdane diterpenoids, which may play a role in the prevention and/or management of cancer.

Anticancer and immunostimulatory compounds from Andrographis paniculata.

A New Diterpene from the Leaves of Andrographis Paniculata Nees

The methanolic extract of the leaves of Andrographis paniculata Nees exhibited moderate antibacterial and antifungal activities at a dose of 200 μg/mL in comparison with the reference standards.