A bisphosphonate monoamide analogue of DOTA: a potential agent for bone targeting.

@article{Kubek2005ABM,
  title={A bisphosphonate monoamide analogue of DOTA: a potential agent for bone targeting.},
  author={Vojtěch Kub{\'i}{\vc}ek and Jakub Rudovsk{\'y} and Jan Kotek and Petr Hermann and Luce Vander Elst and Robert Nathan Muller and Zvonimir I. Kolar and Hubert Th. Wolterbeek and Joop A. Peters and Ivan Luke{\vs}},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 47},
  pages={16477-85}
}
A new macrocyclic DOTA-like ligand (BPAMD) for bone imaging and therapy containing a monoamide bis(phosphonic acid) bone-seeking group was designed and synthesized. Its lanthanide(III) complexes were prepared and characterized by 1H and 31P NMR spectroscopy. The Gd(III)-BPAMD complex was investigated in detail by 1H and 17O relaxometric studies to inspect parameters relevant for its potential application as an MRI contrast agent. Sorption experiments were conducted with Gd(III) and Tb(III… CONTINUE READING

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