A bisphosphonate monoamide analogue of DOTA: a potential agent for bone targeting.

  title={A bisphosphonate monoamide analogue of DOTA: a potential agent for bone targeting.},
  author={V. Kub{\'i}{\vc}ek and Jakub Rudovsk{\'y} and J. Kotek and P. Hermann and L. Vander Elst and R. Muller and Z. I. Kolar and H. Wolterbeek and J. A. Peters and I. Lukeš},
  journal={Journal of the American Chemical Society},
  volume={127 47},
  • V. Kubíček, Jakub Rudovský, +7 authors I. Lukeš
  • Published 2005
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • A new macrocyclic DOTA-like ligand (BPAMD) for bone imaging and therapy containing a monoamide bis(phosphonic acid) bone-seeking group was designed and synthesized. Its lanthanide(III) complexes were prepared and characterized by 1H and 31P NMR spectroscopy. The Gd(III)-BPAMD complex was investigated in detail by 1H and 17O relaxometric studies to inspect parameters relevant for its potential application as an MRI contrast agent. Sorption experiments were conducted with Gd(III) and Tb(III… CONTINUE READING
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