A bispecific antibody against IL-1β and IL-17A is beneficial for experimental rheumatoid arthritis.

@article{Qi2012ABA,
  title={A bispecific antibody against IL-1β and IL-17A is beneficial for experimental rheumatoid arthritis.},
  author={Jianying Qi and Fangming Kan and Xianlong Ye and Mo Guo and Yu Zhang and Guiping Ren and De-shan Li},
  journal={International immunopharmacology},
  year={2012},
  volume={14 4},
  pages={770-8}
}
IL-1β is a pivotal cytokine and plays an important role in rheumatoid arthritis (RA). More recently, the biological therapy targeting this cytokine has been impressively effective for many RA patients, however, it remains insufficient in some patients. One of the reasons for these failures may be due to multiple cytokines involved in the disease process. In the present study, we constructed a single-chain bispecific antibody (scBsAb1/17) against both human IL-1β and human IL-17A which is the… CONTINUE READING

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