A birth in non-mosaic Klinefelter's syndrome after testicular fine needle aspiration, intracytoplasmic sperm injection and preimplantation genetic diagnosis.

@article{Reubinoff1998ABI,
  title={A birth in non-mosaic Klinefelter's syndrome after testicular fine needle aspiration, intracytoplasmic sperm injection and preimplantation genetic diagnosis.},
  author={Benjamin E. Reubinoff and Dvorah Abeliovich and Marion Werner and Joseph G. Schenker and A. P. Safran and Aby Lewin},
  journal={Human reproduction},
  year={1998},
  volume={13 7},
  pages={1887-92}
}
Non-mosaic Klinefelter patients are generally azoospermic due to primary testicular failure. Nevertheless, in some cases, testicular spermatozoa may be recovered and utilized to fertilize oocytes via intracytoplasmic sperm injection (ICSI). As the risk for an increased number of gonosomes in these spermatozoa is unclear, preimplantation genetic diagnosis (PGD) may be attempted in the resulting embryos. In the present study, we report our experience with the combined approach of sperm retrieval… CONTINUE READING

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