A bird's-eye view of sex chromosome dosage compensation.

@article{Arnold2008ABV,
  title={A bird's-eye view of sex chromosome dosage compensation.},
  author={Arthur P Arnold and Yuichiro Itoh and Esther Melamed},
  journal={Annual review of genomics and human genetics},
  year={2008},
  volume={9},
  pages={
          109-27
        }
}
Intensive study of a few genetically tractable species with XX/XY sex chromosomes has produced generalizations about the process of sex chromosome dosage compensation that do not fare well when applied to ZZ/ZW sex chromosome systems, such as those in birds. The inherent sexual imbalance in dose of sex chromosome genes has led to the evolution of sex-chromosome-wide mechanisms for balancing gene dosage between the sexes and relative to autosomal genes. Recent advances in our knowledge of avian… CONTINUE READING
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