A bipolar DNA helicase gene, herA, clusters with rad50, mre11 and nurA genes in thermophilic archaea.

@article{Constantinesco2004ABD,
  title={A bipolar DNA helicase gene, herA, clusters with rad50, mre11 and nurA genes in thermophilic archaea.},
  author={Florence Constantinesco and Patrick Forterre and Eugene V. Koonin and L. Aravind and Christiane Elie},
  journal={Nucleic acids research},
  year={2004},
  volume={32 4},
  pages={
          1439-47
        }
}
We showed previously that rad50 and mre11 genes of thermophilic archaea are organized in an operon-like structure with a third gene (nurA) encoding a 5' to 3' exonuclease. Here, we show that the rad50, mre11 and nurA genes from the hyperthermophilic archaeon Sulfolobus acidocaldarius are co-transcribed with a fourth gene encoding a DNA helicase. This enzyme (HerA) is the prototype of a new class of DNA helicases able to utilize either 3' or 5' single-stranded DNA extensions for loading and… CONTINUE READING

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