A bipartite yeast SSRP1 analog comprised of Pob3 and Nhp6 proteins modulates transcription.

@article{Brewster2001ABY,
  title={A bipartite yeast SSRP1 analog comprised of Pob3 and Nhp6 proteins modulates transcription.},
  author={Neil K. Brewster and Gerald C. Johnston and Richard A. Singer},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 10},
  pages={3491-502}
}
The FACT complex of vertebrate cells, comprising the Cdc68 (Spt16) and SSRP1 proteins, facilitates transcription elongation on a nucleosomal template and modulates the elongation-inhibitory effects of the DSIF complex in vitro. Genetic findings show that the related yeast (Saccharomyces cerevisiae) complex, termed CP, also mediates transcription. The CP components Cdc68 and Pob3 closely resemble the FACT components, except that the C-terminal high-mobility group (HMG) box domain of SSRP1 is not… CONTINUE READING

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