A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis

@inproceedings{Pokorzynski2019ABI,
  title={A bipartite iron-dependent transcriptional regulation of the tryptophan salvage pathway in Chlamydia trachomatis},
  author={Nick D Pokorzynski and Amanda J Brinkworth and Rey A Carabeo},
  booktitle={eLife},
  year={2019}
}
During infection, pathogens are starved of essential nutrients such as iron and tryptophan by host immune effectors. Without conserved global stress response regulators, how the obligate intracellular bacterium Chlamydia trachomatis arrives at a physiologically similar 'persistent' state in response to starvation of either nutrient remains unclear. Here, we report on the iron-dependent regulation of the trpRBA tryptophan salvage pathway in C. trachomatis. Iron starvation specifically induces… CONTINUE READING
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