A biosynthetic pathway for hexanoic acid production in Kluyveromyces marxianus.

  title={A biosynthetic pathway for hexanoic acid production in Kluyveromyces marxianus.},
  author={Yuna Cheon and Jun-Seob Kim and Jun-Bum Park and Paul Heo and Jae Hyung Lim and Gyoo Yeol Jung and Jin-Ho Seo and Jin Hwan Park and Hyun Min Koo and Kwang Myung Cho and Jin‐Byung Park and Suk-Jin Ha and Dae-Hyuk Kweon},
  journal={Journal of biotechnology},

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The strains constructed are a promising platform for the production of aromatic amino acid-based biochemicals, and the results illustrate challenges with attempting to combine individually beneficial modifications in an integrated platform.

A biosynthetic pathway for ethyl butyrate production in Saccharomyces cerevisiae.

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Biological Parts for Kluyveromyces marxianus Synthetic Biology

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Consumer demand for biologically‐synthesized molecules for use in foods and other products creates an opportunity to exploit the unique potential of K. marxianus for this cell factory application.

Genome and metabolic engineering in non-conventional yeasts: Current advances and applications

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The application of a biomass-linked stoichiometric model of central metabolism that is experimentally validated, and mass and charge balanced for assessing the carbon conversion efficiency of wild type and modified K. marxianus is shown.



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To increase knowledge on the biology of this species and to enable the potential applications to be converted into industrial practice, a more systematic approach, including the careful choice of (a) reference strain(s) by the scientific community, would certainly be of great value.

Sequential gene integration for the engineering of Kluyveromyces marxianus.

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This demonstration of 1-hexanol production by extending the 1-butanol pathway provides the possibility to produce other medium chain length alcohols using the same strategy.

ATP drives direct photosynthetic production of 1-butanol in cyanobacteria

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Simultaneous integration of multiple genes into the Kluyveromyces marxianus chromosome.

Expanding metabolism for biosynthesis of nonnatural alcohols

The feasibility of an approach to build artificial metabolism beyond the natural metabolic network is demonstrated by optimizing the biosynthesis of the 6-carbon alcohol, (S)-3-methyl-1-pentanol, which is included in the metabolite family of living systems.