A biosensor assay for studying ligand-membrane receptor interactions: binding of antibodies and HIV-1 Env to chemokine receptors.

@article{Hoffman2000ABA,
  title={A biosensor assay for studying ligand-membrane receptor interactions: binding of antibodies and HIV-1 Env to chemokine receptors.},
  author={Travis L. Hoffman and Gabriela A Canziani and Lingyun Jia and Joseph Rucker and Robert W. Doms},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 21},
  pages={11215-20}
}
The HIV envelope (Env) protein mediates entry into cells by binding CD4 and an appropriate coreceptor, which triggers structural changes in Env that lead to fusion between the viral and cellular membranes. The major HIV-1 coreceptors are the seven transmembrane domain chemokine receptors CCR5 and CXCR4. The type of coreceptor used by a virus strain is an important determinant of viral tropism and pathogenesis, and virus-receptor interactions can be therapeutic targets. However, Envs from many… CONTINUE READING

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