A biophysical study of integral membrane protein folding.

  title={A biophysical study of integral membrane protein folding.},
  author={John Francis Hunt and Thomas N. Earnest and O Bousch{\'e} and Krishna K. Kalghatgi and Kevin C. Reilly and Csaba Horv{\'a}th and Kenneth J Rothschild and Donald M. Engelman},
  volume={36 49},
In order to characterize the thermodynamic constraints on the process of integral membrane protein folding and assembly, we have conducted a biophysical dissection of the structure of bacteriorhodopsin (BR), a prototypical alpha-helical integral membrane protein. Seven polypeptides were synthesized, corresponding to each of the seven transmembrane alpha-helices in BR, and the structure of each individual polypeptide was characterized in reconstituted phospholipid vesicles. Five of the seven… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 31 extracted citations


Publications referenced by this paper.

Biophysical Studies of Integral Membrane Protein Folding

  • J. F. Hunt
  • Ph.D. Thesis,
  • 1993
Highly Influential
20 Excerpts

Similar Papers

Loading similar papers…