A biomechanical regulatory model for periprosthetic fibrous-tissue differentiation.

  title={A biomechanical regulatory model for periprosthetic fibrous-tissue differentiation.},
  author={Rik Huiskes and W. D. van Driel and Patrick J. Prendergast and Kjeld S\oballe},
  journal={Journal of materials science. Materials in medicine},
  volume={8 12},
Loosening of implants in bone is commonly associated with a development of fibrous interface tissues, due to interface gaps and a lack of mechanical stability. It has been postulated that the differentiation of these tissues to fibrocartilage or bone is governed by mechanical stimuli. The objective of our research is to unravel these relationships to the extent that the question whether an implant will loosen can be answered from initial conditions determined by implant and interface morphology… CONTINUE READING
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