A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

@article{Dimri1995ABT,
  title={A biomarker that identifies senescent human cells in culture and in aging skin in vivo.},
  author={Goberdhan P Dimri and X. Lee and G. Basile and M. Acosta and G. Scott and C. Roskelley and E. Medrano and M. Linskens and I. Rubelj and O. Pereira-smith},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 20},
  pages={
          9363-7
        }
}
Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of divisions. This process, termed replicative senescence, is thought to be a tumor-suppressive mechanism and an underlying cause of aging. There is ample evidence that escape from senescence, or immortality, is important for malignant transformation. By contrast, the role of replicative senescence in organismic aging is controversial. Studies on cells cultured from donors of… Expand
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