A bioluminescent sensor for high throughput toxicity classification.

  title={A bioluminescent sensor for high throughput toxicity classification.},
  author={Byoung Chan Kim and Man Bock Gu},
  journal={Biosensors & bioelectronics},
  volume={18 8},
A high throughput toxicity monitoring and classification biosensor system has been successfully developed using four immobilized bioluminescent Escherichia coli strains, DPD2511, DPD2540, DPD2794 and TV1061, which have plasmids bearing a fusion of a specific promoter to the luxCDABE operon. The bioluminescence of DPD2511 increases in the presence of oxidative damage, DPD2540 by membrane damage, DPD2794 by DNA damage and TV1061 by protein damage. In the developed biosensor these strains are… CONTINUE READING
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