A biologically-based dose-response model for developmental toxicology.

@article{Leroux1996ABD,
  title={A biologically-based dose-response model for developmental toxicology.},
  author={Brian G Leroux and Wendy M Leisenring and Suresh H. Moolgavkar and Elaine M. Faustman},
  journal={Risk analysis : an official publication of the Society for Risk Analysis},
  year={1996},
  volume={16 4},
  pages={449-58}
}
The methods currently used to evaluate the risk of developmental defects in humans from exposure to potential toxic agents do not reflect biological processes in extrapolating estimated risks to low doses and from test species to humans. We develop a mathematical model to describe aspects of the dynamic process of organogenesis, based on branching process models of cell kinetics. The biological information that can be incorporated into the model includes timing and rates of dynamic cell… CONTINUE READING

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