A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase

@inproceedings{Christmas2011ABP,
  title={A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase},
  author={David M B Christmas and JP Potokar and Simon JC Davies},
  booktitle={Neuropsychiatric disease and treatment},
  year={2011}
}
This article highlights the evidence linking depression to increased inflammatory drive and explores putative mechanisms for the association by reviewing both preclinical and clinical literature. The enzyme indoleamine 2,3-dioxygenase is induced by proinflammatory cytokines and may form a link between immune functioning and altered neurotransmission, which results in depression. Increased indoleamine 2,3-dioxygenase activity may cause both tryptophan depletion and increased neurotoxic… CONTINUE READING
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